DOI码：10.1016/j.chom.2024.04.002
发表刊物：Cell Host & Microbe
关键字：phase-separated; Fusarium head blight; wheat
摘要：Fusarium head blight (FHB) is a devastating wheat disease. Fhb1, the most widely applied genetic locus for FHB resistance, is conferred by TaHRC of an unknown mode of action. Here, we show that TaHRC alleles distinctly drive liquid-liquid phase separation (LLPS) within a proteinaceous complex, determining FHB susceptibility or resistance. TaHRC-S (susceptible) exhibits stronger LLPS ability than TaHRC-R (resistant), and this distinction is further intensified by fungal mycotoxin deoxynivalenol, leading to opposing FHB symptoms. TaHRC recruits a protein class with intrinsic LLPS potentials, referred to as an HRC-containing hub. TaHRC-S drives condensation of hub components, while TaHRC-R comparatively suppresses hub condensate formation. The function of TaSR45a splicing factor, a hub member, depends on TaHRC-driven condensate state, which in turn differentially directs alternative splicing, switching between susceptibility and resistance to wheat FHB. These findings reveal a mechanismfor FHB spread within a spike and shed light on the roles of complex condensates in controlling plant disease.
论文类型：Research Article
卷号：32
页面范围：1-17
是否译文：否
发表时间：2024-04-23
收录刊物：SCI