Research Focus

一、主持项目：

1.国家自然科学基金面上项目：基于ACE2-CAV1互作双核心分子网络正反馈血管内皮细胞稳态探讨益气活血祛瘀法治疗气虚血瘀型缺血性卒中的作用机制，82274392。

2.国家留学基金委创新型人才国际合作培养项目：中医药+健康老龄化综合型医学人才培养项目，CXXM2110100036。

3.国家自然科学基金青年项目：IGF-R/PI-3K/Akt信号通路对幼及成年缺血性脑卒中模型所致神经损伤的作用机制比较，81401005。

4.中国博士后科学基金特别资助项目：ERK1/2通路对BBB-TJ的调节在幼年缺血性卒中的作用, 2014M561720。

5.江苏省自然科学基金：RhoA/ROCK信号通路对BBB-TJ连接蛋白的调节在幼年缺血性脑卒中的作用，BK20140494

6.江苏省高校自然科学研究面上项目：PI-3K-Akt信号通路对幼年缺血性脑卒中的作用，14KJB310027

7.江苏省高校自然科学研究重大项目：MiR144/451对卒中后神经干细胞分化的作用，16KJA310006。

8.江苏省博士后科学基金（神经营养因子激活PI-3K/Akt信号通路对幼年缺血性脑卒中的作用机制1401155C。

二、近5年代表性论著：

1．Wang J, Xia Z, Sheng P, Shen M, Ding L,Liu D*,Bing Chun Yan﹡.Enhanced autophagy interacting proteins negatively correlated with the activation of apoptosis-related caspase family proteins after focal ischemic stroke of young rats. BMC Neurosci. 2022 Sep 28;23(1):55.

2．Zhao L, Ding LD,Xia ZH, Sheng P, Shen MM, Cai ZM,Bing Chun Yan﹡. A Network-Based Approach to Investigate the Neuroprotective Effects and Mechanisms of Action of Huangqi-Chuanxiong and Sanleng-Ezhu Herb Pairs in the Treatment of Cerebral Ischemic Stroke. Front Pharmacol. 2022 Mar 23;13:844186.

3．Wang J, Xia Z, Sheng P, Rui Y, Cao J, Zhang J, Gao M, Wang L,Yu D﹡,Bing Chun Yan*. Targeting MicroRNA-144/451-AKT-GSK3βAxis Affects the Proliferation and Differentiation of Radial Glial Cells in the Mouse Hippocampal Dentate Gyrus. ACS Chem Neurosci. 2022 Apr 6;13(7):897-909.

4．Wang F, Xia Z,Sheng P, Ren Y, Liu J, Ding L,Bing Chun Yan﹡. Targeting the Erk1/2 and autophagy signaling easily improved the neurobalst differentiation and cognitive function after young transient forebrain ischemia compared to old gerbils. Cell Death Discov. 2022 Feb 26;8(1):87.

5．Jiajia Liu,FuxingWang,PengSheng,ZihaoXia,YunyaoJiang,Bing Chun Yan﹡.A network-based method for mechanistic investigation and neuroprotective effect on treatment of tanshinoneⅠagainst ischemic stroke in mouse.J Ethnopharmacol. 2021 May 23;272:113923.

6．Bing Chun Yan,Jianwen Cao, Jiajia Liu, Yunhao Gu, Zhuobin Xu, Dandan Li, Lizeng Gao Dietary Fe³O⁴Nanozymes Prevent the Injury of Neurons and Blood-Brain Barrier Integrity from Cerebral Ischemic Stroke.ACS Biomater Sci Eng. 2021 Jan 11;7(1):299-310

7．Jie Zhang, Yanggang Rui, Manman Gao , Li Wang ,Bing Chun Yan﹡.Expression of Long Non-coding RNA RGD1566344 in the Brain Cortex of Male Mice After Focal Cerebral Ischemia-Reperfusion and the Neuroprotective Effect of a Non-coding RNA RGD1566344 Inhibitor. Cell Mol Neurobiol.2020 May 18.doi:10.1007/s10571-020-00877-4.

8．Jianwen Cao, Cheng Tang,Manman Gao, Yanggang Rui, Jie Zhang, Li Wang, Yang Wang, Bo Xu,Bing Chun Yan﹡.Hyperoside alleviates epilepsy-induced neuronal damage by enhancing antioxidant levels and reducing autophagy.J Ethnopharmacol. 2020 Apr 18;257:112884.

9．Zhang Hong Xiao, Li Wang,Ping Gan, Jing He,Bing Chun Yan﹡, Li Dong Ding﹡.Dynamic Changes in miR-126 Expression in the Hippocampus and Penumbra Following Experimental Transient Global and Focal Cerebral Ischemia-Reperfusion. Neurochem Res. 2020 May;45(5):1107-1119.

10．Jie Zhang, Yunyao Jiang,Nan Liu, Ting Shen, Hyo Won Jung,Jianxun Liu,Bing Chun Yan﹡.A Network-Based Method for Mechanistic Investigation and Neuroprotective Effect on Post-treatment of Senkyunolid-H Against Cerebral Ischemic Stroke in Mouse. Front Neurol. 2019 Dec 19;10:1299.

11．Bing Chun Yan﹡, Jie Wang,Yanggang Rui, Jianwen Cao, Pei Xu, Dan Jiang, Xiaolu Zhu, Moo-Ho Won, Ping Bo, Peiqing Su. Neuroprotective Effects of Gabapentin Against Cerebral Ischemia Reperfusion-Induced Neuronal Autophagic Injury via Regulation of the PI3K/Akt/mTOR Signaling Pathways. J Neuropathol Exp Neurol. 2019 Feb 1;78(2):157-171.

12．Bing Chun Yan﹡,Pei Xu,Manman Gao, Jie Wang, Dan Jiang, Xiaolu Zhu, Moo-Ho Won, Pei Qing Su. Changes in the Blood-Brain Barrier Function Are Associated With Hippocampal Neuron Death in a Kainic Acid Mouse Model of Epilepsy. Front Neurol. 2018 Sep 12;9:775.

13．Bing Chun Yan﹡, Dan Jiang,Jie Wang, Yuanyuan Zhang, Xiaolu Zhu, Pei Xu, Xing Yu, Moo-Ho Won, Pei Qing Su. Both Decreased Akt Expression and mTOR Phosphorylation Are Related to Decreased Neuronal Differentiation in the Hippocampal Alveus of Aged Mice. Aging Clin Exp Res. 2018 Jul;30(7):737-743.

14．Zi-Gang Zhang,Xin Wang, Jin-Hai Zai, Cai-Hua Sun,Bing Chun Yan﹡.Icariin Improves Cognitive Impairment After Traumatic Brain Injury by Enhancing Hippocampal Acetylation. Chin J Integr Med. 2018 May;24(5):366-371.

15．Bing Chun Yan﹡, Jie Wang,Jianwen Cao, Moo-Ho Won. Less Hippocampal Neuronal Death in Young Gerbils Following Transient Global Cerebral Ischemia Is Associated With Long-term Maintenance of Insulin-like Growth Factor 1 and Its Receptors in the Hippocampal CA1 Region. Mol Med Rep. 2018 Feb;17(2):3055-3061.

16．Bing Chun Yan﹡, Hui Shen,Yuanyuan Zhang, Xiaolu Zhu, Jie Wang, Pei Xu, Dan Jiang, Xing Yu. The Antiepileptic Drug Levetiracetam Promotes Neuroblast Differentiation and Expression of Superoxide Dismutase in the Mouse Hippocampal Dentate Gyrus via PI3K/Akt Signalling. Neurosci Lett. 2018 Jan 1;662:84-90.

17．Hui Shen, Jie Wang,Dan Jiang, Pei Xu, Xiaolu Zhu, Yuanyuan Zhang, Xing Yu, Moo-Ho Won,Pei Qing Su,Bing Chun Yan﹡.Topiramate Improves Neuroblast Differentiation of Hippocampal Dentate Gyrus in the D-Galactose-Induced Aging Mice via Its Antioxidant Effects.Cell Mol Neurobiol. 2017 Jul;37(5):869-877.

三、获奖经历：

1.中国商业联合会科技进步三等奖。

2.江苏省中西医结合十佳青年之星；

3.扬州市绿扬金凤人才计划。

4.扬州市自然科学优秀学术论文三等奖。