教授，博士生导师。 1988年获江苏农学院农学学士学位，2002年获扬州大学作物遗传育种硕士学位，2007年获扬州大学作物遗传育种博士学位，2008年入选扬州大学“新世纪人才工程”中青年学术带头人，2013年入选江苏省“六大人才高峰”高层次人才选拔培养对象。江苏省遗传学会、中国遗传学会和中国植物生理学会女科学家分会会员。分别于2001年11月至2002年1月、2005年12月至2006年11月和2011年10月至2012年12月在香港科技大学、香港中文大学和美国威斯康辛大学进行合作研究。

主要从事作物遗传育种的教学与科研工作，主讲课程包括《作物遗传育种前沿》、《植物生物技术》，《遗传学》、《植物遗传学》、《植物组织培养技术》。参与建设的“遗传学”课程为江苏省普通高校壹类优秀课程，“遗传学教学建设”教改研究项目于2000年获得扬州大学农学院优秀教学成果奖，“更新内容、改革方法、提高遗传学课程教学质量的研究与实践”于2004年获得扬州大学优秀教学成果三等奖。

主要研究方向包括：水稻分子细胞遗传学和水稻转基因技术及转基因育种等研究工作。先后主持国家自然科学基金、国家转基因专项、国家重点研发计划子课题和国家重点实验室开放课题等项目10余项，参加了多项国家级和部省级的科研项目。参与了水稻成套初级三体、端三体、次级三体和单端体等一系列水稻非整倍体的选育、鉴定和保存等工作，这是目前国际上最全的一套水稻非整倍体材料，这些材料在水稻结构基因组学研究（如一些间隙大小的测定）中起了重要作用；开展了水稻细胞分裂相关基因的克隆和功能研究；开展了野生稻有利基因的育种应用研究。在以基因工程技术培育优质、抗逆转基因水稻新品种研究中，已将多个与水稻品质及抗性有关的基因，如反义Wx基因、反义分支酶基因、Bt基因和AP1基因等导入到了多个高产水稻品种或杂交稻重点亲本中，获得了大量转基因水稻植株，并已经获得一些较优良的后代，已有多份材料获得农业部转基因水稻安全评价进入中间试验或环境释放阶段。获得教育部提名国家科学技术奖自然科学一等奖和上海市科学技术进步一等奖各一项，申请发明专利8项，参与育成水稻品种5个，发表学术论文50余篇。指导的研究生论文1篇获得江苏省优秀博士论文，1篇获得江苏省优秀硕士论文。

招生专业：作物遗传育种、植物生物技术

研究方向：植物分子细胞遗传学、分子生物学技术在作物改良中的应用

 

近年来发表的主要研究论文

      1. Zhang C, Zhang JX, Tang YJ, Liu KW, Liu Yan, Zhang T, Yu HX. 2021. DEEP GREEN PANICLE 1 suppresses the transcriptional activity of OsGLK to reduce chlorophyll                  synthesis in rice glumes. Plant Physiology 185: 496-477.

2. Zhang C, Zhang FF, Cheng XJ, Liu KW, Tang JQ, Li YF, Tang D, Cheng ZK, Yu HX. 2020. OsATM safeguards accurate repair of meiotic double-strand breaks in rice. Plant Physiology 183: 1047-1057.

3. Xu Z, Zhang JX, Cheng XJ, Tang YJ, Gong ZY, Gu MH, Yu HX. 2020. COM1, a factor of alternative non ‐ homologous end joining (NHEJ), lagging behind the classic NHEJ pathway in rice somatic cells. The Plant Journal 103:140-153.

4. Xu ZH , Yu MM, Yin YW, Zhu CW, Ji W, Zhang CQ, Li QF, Zhang H,Tang SZ, Yu HX, Liu QQ. 2020. Generation of selectable marker-free soft transgenic rice with transparent kernels by downregulation of SSSII-2. The Crop Journal, 8( 1):53-61.

5.  Wang B, Huang J, Zhang ML, Yun Wang L, Yu HX, Shao MW, Kang ZH. 2020. Carbon Dots Enable Efficient Delivery of Functional DNA in Plants, ACS Appl. Bio Mater. 3, 12, 8857–8864。

6. Xu M, Tang D, Cheng XJ, Zhang JX, Tang YJ, Tao QD, Shi WQ, You AQ, Gu MH, Cheng ZK, Yu HX. 2019. OsPINOID regulates stigma and ovule initiation through maintenance of the floral meristem by auxin signaling. Plant Physiology 180: 952-965.

7. Xu Z, Zhang JX, Xu M, Ji W, Yu MM, Tao YJ, Gong ZY, Gu MH, Yu HX. 2018. Rice RAD51 paralogs play essential roles in somatic homologous recombination for DNA repair. The Plant Journal 95: 282-295.

8. Hou LL, Xu M, Zhang T, Xu ZH, Wang WY, Zhang JX, Yu MM, Ji W, Zhu CW, Gong ZY, Gu MH, Yu HX. 2018. Chromosome painting and its applications in cultivated and wild rice. BMC Plant Biology 18: 110.

9. Mohamed M. S. Ahmed, Ji W, Wang MY, Bian SQ, Xu M, Wang WY, Zhang JX, Zhihao Xu, Yu MM, Liu QQ, Zhang CQ, Zhang HG,Tang SZ, Gu MH, Yu HX. 2017. Transcriptional changes of rice in response to rice black-streaked dwarf virus. Gene 628: 38-47.

10. Mohamed M. S. Ahmed, Bian SQ, Wang MY, Zhao J, Zhang BW, Liu QQ, Zhang CQ, Tang SZ, Gu MH, Yu HX. 2017. RNAi-mediated resistance to rice black-streaked dwarf virus in transgenic rice. Transgenic Research 26:197-207.

11. Zhang BW, Wang M, Tang D, Li YF, Xu M, Gu MH, Cheng ZK, Yu HX. 2015. XRCC3 is essential for proper double-strand break repair and homologous recombination in rice meiosis. Journal of Experimental Botany 66: 5713-5725.

12. Yu HX, Wang M, Tang D, Chen FL, Gong ZY, Gu MH, Cheng ZK. 2010. OsSPO11 is essential for both homologous chromosome pairing and crossover formation in rice. Chromosoma 119: 625-636.

13. Yu HX, Liu QQ, Xu L, Lu MF, Yang XJ, Gong ZY, Cai XL, Zhang YS, Zhang CQ, Wang ZY and Gu MH. (2009). Quality characteristics and field performance of selectable marker-free transgenic rice with antisense Wx gene and improved quality derived from the elite parents of hybrid indica rice. Journal of Cereal Science, 50: 370–375.

14. Yu HX, Yao QH,  Wang L,  Zhao ZP,  Gong ZY,  Tang SZ,  Liu QQ and Gu MH. (2009). Generation of  selectable  marker-free  transgenic rice resistant to chewing insects using two co-transformation systems. Progress in Natural Science, 19: 1485-1492.

15. Yu HX, Lu MF, Chen XH, Gong ZY, Liu QQ and Gu MH. (2009). Efficiencies of generating selectable marker-free transgenic rice with different transformation methods. Rice Science, 16: 254–260.

16. Yu HX, Wang X, Gong ZY, Tang D, Gu MH and Cheng ZK. (2008). Generating of rice OsCENH3-GFP transgenic plants and their genetic applications. Chinese Science Bulletin, 53: 2981-2988.

17. Yu HX, Liu QQ, Wang L, Zhao ZP, Xu L, Huang BL, Gong ZY, Tang SZ and Gu MH. (2006). Breeding of selectable marker-free transgenic rice lines containing AP1 gene with enhanced disease resistance, Agricultural Sciences in China, 5:812-819

18. Yu HX, Gong ZY, Su Y, Gu MH. Isolation and identification of the three rice monotelosomics. Chinese Science Bulletin, 2005，50(19): 2182-2186

19. Zhao TT, Ren LJ, Chen XJ, Yu HX, Cheng ZK. 2018. The OsRR24/LEPTO1 type-B response regulator is essential for the organization of leptotene chromosomes in rice meiosis. The Plant Cell 30: 3024-3037.

20. PanXC, Fang Y, Yang XM, Zheng DY, Chen LF, Wang L, Xiao J, Wang X, Wang K, Cheng ZK, Yu HX, Zhang WL.2017. Chromatin states responsible for the regulation of differentially expressed genes under 60Co~γ ray radiation in rice. BMC Genomics,18:778

21. Xue ZH, Li YF, Zhang L, Shi WQ, Zhang C, Feng MS, Zhang FF, Tang D, Yu HX, Gu MH and Cheng ZK. 2016. OsMTOPVIB Promotes Meiotic DNA Double-Strand Break Formation in Rice. Molecular Plant 9: 1535-1538.

22. Che LX, Wang KJ, Tang D, Liu QQ, Chen XJ, Li YF, Hu Q, Shen Y, Yu HX, Gu MH, Cheng ZK. 2014. OsHUS1 facilitates accurate meiotic recombination in rice. PLoS Genetics 10: e1004405.

23. Tang D, Miao CB, Li YF, Wang HJ, Liu XF, Yu HX, Cheng ZK. 2014. OsRAD51C is essential for double-strand break repair in rice meiosis. Frontiers in Plant Science 5:167.

24. Miao CB, Tang D, Zhang H, Wang M, Li YF, Tang SZ, Yu HX, Gu MH, Cheng ZK. 2013. Central region component1, a novel synaptonemal complex component, is essential for meiotic recombination initiation in rice. The Plant Cell 25(8): 2998-3009.

25. Che LX, Tang D, Wang KJ, Wang M, Zhu KM, Yu HX, Gu MH, Cheng ZK. 2011. OsAM1 is required for leptotene-zygotene transition in rice. Cell Research 21: 654-665.

26. Shao T, Tang D, Wang KJ, Wang M, Che LX, Qin BX, Yu HX, Li M, Gu MH, and Cheng ZK. 2011. OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis. Plant Physiology 156:1386-1396.

27. Qin BX, Tang D, Huang J, Li M, Wu XR, Lu LL, Wang KJ, Yu HX, Chen JM, Gu MH, Cheng ZK. 2011. Rice OsGL1-1 Is Involved in Leaf CuticularWax and Cuticle Membrane. Molecular Plant, 1–11

28. Gong ZY, Liu X, Tang D, Yu HX, Gu MH. 2011. Pairing and crossing over of non-homologous chromosomes during meiosis in a haploid rice. Chromosoma, 120:47–60.

29. Zhang CQ, Xu Y, Lu Y, Yu HX, Gu MH, Liu QQ. 2011.The WRKY transcription factor OsWRKY78 regulates stem elongation and seed development in rice. Planta, 234:541–554

30. Huang J, Wang X, Yu HX, Gu MH, Cheng ZK. 2010. Activation of gibberellin 2-oxidase 6 decreases active gibberellin levels and creates a dominant semi-dwarf phenotype in rice (Oryza sativa L.), Journal of Genetics and Genomics, 37:1-14.

31. Zhu KM, Tang D, Yan CJ, Chi ZC, Yu HX, Cheng ZK. 2010. ERECT PANICAL2 Encodes a Novel Protein That Regulates Panicle Erectness in Indica Rice. Genetics, 184:1-8.

32. Wang K, Tang D, Wang M, Lu JF, Yu HX, Liu J, Qian BX, Gong ZY, Wang X, Chen JM, Gu MH, Cheng ZK. 2009. MER3 is required for normal meiotic crossover formation, but not for presynaptic alignment in rice. Journal of Cell Science , 122: 2055–2063.

33. Gong ZY, Yu HX, Huang J, Yi CD, Gu MH. 2009. Unstable transmission of rice chromosomes without functional centromeric repeats in asexual propagation. Chromosome Research, 17:863–872.

34. Wang K, Tang D, Wang M, Lu JF, Yu HX, Liu J, Qian BX, Gong ZY, Wang X, Chen JM, Gu MH, Cheng ZK. 2009. MER3 is required for normal meiotic crossover formation, but not for presynaptic alignment in rice. J. Cell Science 122: 2055–2063.

35. Yang ZQ, Liu QQ, Pan ZM, Yu HX, Jiao XA. 2007. Expression of the fusion glycoprotein of newcasstle disease virus in transgenic rice and its immunogenicity in mice. Vaccine, 25: 591-598

36. Liu QQ, Li QF, Cai XL, Wang HM, Tang SZ, Yu HX, Wang ZY, Gu MH. 2006. Molecular marker-assisted selection for improved cooking and eating quality of two elite parents of hybrid rice. Crop Science, 46: 2354-2360

37. 龚志云，石国新，刘秀秀，裔传灯，于恒秀. 水稻非整倍体无性繁殖过程中的遗传稳定性. 作物学报, 2011, 37(9): 1505−1510.

38. 于恒秀，陆美芳，陈秀花，龚志云，刘巧泉，顾铭洪，不同转化方法培育无抗性选择标记转基因水稻效率的比较, 中国水稻科学, 2009, 23(2): 120-126

39. 于恒秀，刘巧泉，徐 丽，陆美芳， 蔡秀玲， 龚志云，裔传灯，王宗阳，顾铭洪，无抗性选择标记转基因软米和糯稻新品系的选育及中间试验, 作物学报, 2009, 35(6): 967−973

40. 于恒秀，刘巧泉，赵志鹏，王玲，顾铭洪. 导入GNA和Bar基因获得抗褐飞虱和抗除草剂的转基因水稻. 植物保护学报，2007, 34(5): 555-556

41. 于恒秀，刘巧泉, 王玲, 黄健，王为成，李凝， 顾铭洪. 根癌农杆菌介导的水稻成熟胚转化系统的优化及转metr基因植株的获得. 遗传，2005, 27(5): 756-762

42. 王歆, 于恒秀, 龚志云, 唐丁, 顾铭洪, 程祝宽. OsCENH3-GFP 融合转基因水稻的获得及其遗传应用. 科学通报, 2008, 53(16): 1902-1908

43. 龚志云, 高清松，于恒秀，裔传灯，顾铭洪. 水稻端四体材料的分子细胞学鉴定及其染色体行为分析. 中国水稻科学，2008, 22(4):335-339

44. 龚志云，于恒秀，苏艳，裔传灯，顾铭洪. 水稻无性繁殖过程中第8号染色体单体的发现及其分子细胞学鉴定. 自然科学进展, 2008, 18(12): 1507-1512

45. 王歆, 于恒秀, 唐丁, 裔传灯, 程祝宽. RNA干涉水稻端粒酶再生植株的初步研究. 扬州大学学报, 2008, 29(4): 54-58

  46. 龚志云，裔传灯，于恒秀. 植物体细胞无性系变异的研究进展.中国农学通报, 2008, 24(7): 65-68

专利

      1. 于恒秀，张韬，程祝宽，候莉莉，沈懿，龚志云，顾铭洪，一种特异识别栽培稻第9号染色体整条短臂的寡核苷酸文库及识别方法, 中国，ZL 201710442531.X  

      2. 于恒秀，朱岑文，张超，王为云，刘岩，张建祥，张韬，龚志云，程祝宽，沈懿，刘向东，顾铭洪，一种鉴定CC染色体组野生稻的PCR引物及其鉴定方法，中国，申请号：201910725242.X

      3. 于恒秀，程祝宽，刘巧泉，冯梦诗，梁国华，张昌泉，汤述翥，张宏根，裔传灯，龚志云，顾铭洪, 提高水稻智能不育系繁种产量的新方法, 2014.12.12, 中国, 201410769239.5

      4. 于恒秀，刘巧泉，梁国华，程祝宽，冯梦诗，张昌泉，汤述翥，张宏根，裔传灯，龚志云， 顾铭洪, 利用对除草剂的敏感性培育高效水稻智能不育系的新方法, 2014.9.9, 中国, 201410456559.5    

      5. 于恒秀，刘巧泉，张炳为，赵静，张昌泉，汤述翥，张宏根，裔传灯，龚志云，顾铭洪, 一种抗黑条矮缩病水稻的培育方法, 2013.10.25, 中国, CN201310507942.4    

      6. 刘巧泉，李娟，张昌泉，蒋美艳，于恒秀，顾铭洪, 一种优良食味品质转基因水稻及培育方法, 2013.3.19, 中国, CN201310087162.9 

学术奖励

   1. Oligopainting在水稻染色体识别中的应用, 江苏省优秀硕士论文, 2018 (指导教师).

   2. 水稻减数分裂基因OsXRCC3的克隆和功能鉴定, 江苏省优秀博士论文, 2016 (指导教师).     

   3. 江苏省“六大人才高峰”高层次人才选拔培养对象, 江苏省人力资源和社会保障厅, 2013

 4. 教育部提名国家科学技术奖自然科学一等奖,水稻染色体的分子细胞学研究, 2005(顾铭洪, 程祝宽, 朱立煌, 蒋继明, 于恒秀, 汤述翥, 严长杰, 梁国华, 刘巧泉, 裔传灯).