胡娇，女，博士，中共党员，教授/博导,中国畜牧兽医学会禽病学分会理事。主要从事动物流感病毒致病机理和重要水禽疫病致病机理和新型防控制剂研究。主持包括国家重点研发计划课题、国家自然科学基金、江苏省自然科学基金、江苏省农业自主创新基金等课题10项。以第1作者/通讯作者在Antiviral Research、Journal of Virology等杂志发表论文36篇，单篇最高他引80次；获江苏省科学技术奖二等奖1项（排名第3）、获江苏省青蓝工程“优秀青年骨干教师”人才计划、获扬州大学高端人才“拔尖人才”支持计划、获扬州大学“最受学生欢迎班主任”、“优秀教师”、“科技先锋”等称号；申请国家发明专利10项，授权5项；获批国家计算机软件著作权2项；参与获国家新兽药证书2项，担任了Animals and Zoonoses杂志青年编委。

一、主持科研项目

1.      《宿主LncRNA#61与病毒PA-X蛋白互作抑制禽流感病毒复制的分子机制. 2024.01-2027.12.国家自然科学基金面上项目.50万. 项目编号：32372976

2.      《新鉴定PA-X “host-shutoff”功能区调控H7N9禽流感病毒毒力的机制》. 2021.1-2024.12. 国家自然科学基金面上项目.58万. 项目编号：32072832

3.      《基于红细胞膜纳米囊泡靶向递送H7N9禽流感病毒样颗粒的关键技术研究》. 2021.6-2024.7. 江苏省农业自主创新基金.30万. 项目编号：CX(21)3141

4.      《种禽场高致病性禽流感鉴别诊断和监测技术集成与示范研究》. 2016.7-2021.6. 国家重点研发计划 .200万. 项目编号：2016YFD0501601

5.      《高致病性H5N1禽流感病毒PA相互作用宿主蛋白的鉴定及功能分析》.2016.1- 2018.12. 国家自然科学青年基金 .24万. 项目编号：31502076

6.      《流感病毒新发现PA-X蛋白致病机理研究》.2016.7- 2018.7. 中国博士后特别资助计划 .15万. 项目编号：2016T90515

7.      《流感病毒PA蛋白与宿主蛋白相互作用及其分子机制研究》. 2015.7-2018.6. 江苏省自然科学青年基金. 20万.项目编号：BK20150444

8.      《H5N1禽流感病毒感染宿主细胞差异lncRNA的筛选及分析》.2015.7- 2017.6. 江苏省博士后科学基金. 5 万.项目编号：1501015B

9.      《高致病性H5N1禽流感病毒PA蛋白与宿主互作研究》. 2015.7- 2017.6. 江苏省高校自然科学面上项目. 3万.项目编号：15KJB230006

10.    《H5N1亚型禽流感病毒（AIV）致病哺乳动物的分子机制》.2011.7-2012.6江苏省普通高校研究生科研创新计划项目.3万.项目编号：CXZZ11-0995

二、代表性研究论文

1.Hu J, Zeng Z, Chen X, Zhang M, Hu Z, Gu M, Wang X, Gao R, Hu S, Chen Y, Liu X, Peng D, Liu X. Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice. Virol Sin. 2023 Dec 14:S1995-820X(23)00155-4. doi: 10.1016/j.virs.2023.12.003. 

2. Jiao Hu, Lei Zhang, Xinxin Zheng, Guoqing Wang, Xia Chen, Zenglei Hu, Yu Chen, Xiaoquan Wang, Min Gu, Ruyi Gao, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Jiao Hu(*),Xiufan Liu.Long noncoding RNA #61 exerts a broad anti-influenza a virus effect by its long arm rings. Antiviral Research,Volume 215, July 2023, 105637.

3. Lei Zhang, Xinxin Zheng, Jun Li, Guoqing Wang, Zenglei Hu, Yu Chen, Xiaoquan Wang, Min Gu, Ruyi Gao, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Jiao Hu(*),Xiufan Liu.Long noncoding RNA#45 exerts broad inhibitory effect on influenza a virus replication via its stem ring arms. Virulence.2021 Dec;12(1):2443-2460.

4. Hu, J (#).,Y.Mo, X. Wang, M. Gu, Z. Hu, L. Zhong, Q. Wu, X. Hao, S. Hu, W. Liu, H. Liu, X. Liu and X. Liu（*）. PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus replication and Host Response.Journal of virology. 2015 Apr 15;89(8):4126-42.

5. Hu, J (#)., Z. Hu, Q. Song, M. Gu, X. Liu, X. Wang, S. Hu, C. Chen, H. Liu, S. Chen, D.Peng, X. Liu（*）. The PA gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of avian influenza H5N1 virus in mice.Journal of virology. March 2013;87:2660-2672.

6. Hu, J (#).,Z. Hu, Y. Mo, Q. Wu, Z. Cui, Z. Duan, J. Huang, H. Chen, Y. Chen, M. Gu, X. Wang, S. Hu, H. Liu, X. Liu and X. Liu（*）. The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Responsein the Brain Contribute to the High Pathogenicity of H5N1 Avian InfluenzaVirus in Mallard Ducks. Journal of virology. October 2013,87: 11063–11075.

7. Jun Li^(#), Rumeng Li^(#), Qi Zhang, Peipei Peng, Xiaoquan Wang, Min Gu, Zenglei Hu, Xinan Jiao, Daxin Peng, Jiao Hu^(*), Xiufan Liu. H7N9 Influenza Virus-Like Particles based on BEVS Protects Chickens from Lethal Highly Pathogenic H7N9 Virus Challenge. Veterinary Microbiology. 2021.10.1016/j.vetmic.2021.109106.

8. Jiao Hu^(#), Peipei Peng^(#), Jun Li, Zenglei Hu, Xiaoquan Wang, Min Gu, Rumeng Li, Chunxi Ma, Xiaowen Liu, Shunlin Hu, Sujuan Chen, Daxin Peng, Xinan Jiao, Xiufan Liu^(*).Single Dose of Bivalent H5 and H7 Influenza Virus-Like Particle Protects Chickens Against Highly Pathogenic H5N1 and H7N9 Avian Influenza Viruses. 2021. Frontiers in Veterinary science. 10.3389/fvets.2021.774630  

9. Jiao Hu^(#), Qi Zhang^(#), Jun Li, Zenglei Hu, Xiaoquan Wang, Min Gu, Rumeng Li, Chunxi Ma, Xiaowen Liu, Shunlin Hu, Sujuan Chen, Daxin Peng, Xinan Jiao, Xiufan Liu^(*). Baculovirus-derived influenza virus-like particle confers complete protection against lethal H7N9 avian influenza virus challenge in chickens and mice. Veterinary Microbiology. 2021. 10.1016/j.vetmic.2021.109306. Epub 2021 Dec 14.

10. Lei Zhang, Xinxin Zheng, Jun Li, Guoqing Wang,Zenglei Hu,Yu Chen,Xiaoquan Wang,Min Gu, Ruyi Gao, Shunlin Hu,Xiaowen Liu,Xinan Jiao,Daxin Peng, Jiao Hu^(*), Xiufan Liu.Long noncoding RNA#45 exerts broad inhibitory effect on influenza a virus replication via its stem ring arms. Virulence. 2021 Dec;12(1):2443-2460.doi: 10.1080/21505594.2021.1975494.

11. Guoqing Wang(#), Dong Liu(#), Jiao Hu(#), Min Gu, Xiaoquan Wang, Dongchang He, Lei Zhang, Jun Li, Xinxin Zheng, Zixiong Zeng, Huimou Liu,Shunlin Hu, Daxin Peng, Xinan Jiao, Xiufan Liu (*) .Mutations during the adaptation of H7N9 avian influenza virus to mice lungs enhance human-like sialic acid binding activity and virulence in mice.Veterinary Microbiology. 2021. Jan 20;254. DOI: 10.1016/j.vetmic.2021.109000.

12. Ming Kong(#), Kaibiao Chen, Zixiong Zeng, Xiaoquan Wang, Min Gu, Zenglei Hu, Xinan Jiao, Jiao Hu(*), Xiufan Liu(*).The virulence modulator PA-X protein has minor effect on the pathogenicity of the highly pathogenic H7N9 avian influenza virus in mice. Veterinary Microbiology. 2021. February.DOI: 10.1016/j.vetmic.2021.109019.

13.Jiao Hu(#), Lei Zhang, Xiufan Liu(*). Role of Post-translational Modifications in Influenza A Virus Life Cycle and Host Innate Immune Response. Front. Microbiol. 2020.11:517461.doi: 10.3389/fmicb.2020.51746.

14.Jiao Hu(#), Ming Kong, Zhu Cui, Zhao Gao, Chunxi Ma, Zenglei Hu, Xinan Jiao, Xiufan Liu(*). PA-X protein of H5N1 avian influenza virus inhibits NF-kappaB activity, a potential mechanism for PA-X counteracting the host innate immune responses. Veterinary Microbiology. 2020. Nov;250. DOI：10.1016/j.vetmic.2020.108838

15.Jiao Hu(#), Yanyan Liang(#), Zenglei Hu, Xiaoquan Wang, Min Gu, Rumeng Li, Chunxi Ma, Xiaowen Liu, Shunlin Hu, Sujuan Chen, Daxin Peng, Xinan Jiao, Xiufan Liu(*). Recombinant baculovirus vaccine expressing hemagglutinin of H7N9 avian influenza virus confers full protection against lethal highly pathogenic H7N9 virus infection in chickens. Archives of virology. 2019 Mar;164(3):807-817.

16.孙一宁，王翊珺，张 蕾，郑新新，王国庆，胡 娇*.LncRNA 053065对高致病性H5N1亚型禽流感病毒复制能力的影响及其机制初步探索.中国家禽. 2021.第43卷第9期。

17.郑新新(#)，王国庆，张 蕾，胡 娇(*). 长链非编码RNAs在调控流感病毒复制中的作用.中 国 预 防 兽 医 学 报. 2020. 第42卷 第7期。 

18.李如梦(#),梁艳艳,李军,马春喜,何丽红,刘东,胡娇(*).不同年代的低致病性HH7N9亚型禽流感病毒对SPF鸡致病性的研究中国家禽. 2019.第41卷第14期。

19.孙一(#),何丽红,刘东,胡娇(*),刘秀梵(*).表达高致病性H7N9亚型禽流感病毒血凝素蛋白的重组杆状病毒疫苗候选株的构建与免疫效果评估.中国家禽. 2019.第41卷第18期。

20.马春喜(#)，宋可可，胡娇，刘秀梵(*). 多肽在流感病毒研究中的应用.中国家禽.2018.第40卷第24期。

21. Jiao Hu^(#), Zenglei Hu^(#), Xiaoquan Wang, Min Gu, Zhao Gao, Yanyan Liang, Chunxi Ma, Xiaowen Liu, Shunlin Hu, Sujuan Chen, Daxin Peng, Xinan Jiao, and Xiufan Liu(*). Deep sequencing of the mouse lung transcriptome reveals distinct long non-coding RNAs expression associated with the high virulence of H5N1 avian influenza virus in mice.Virulence. 2018;9(1):1092-1111. doi: 10.1080/21505594.2018.1475795.

22.Jiao Hu(#), Chunxi Ma, Xiufan Liu(*). PA-X: a key regulator of influenza A virus pathogenicity and host immune responses. Med Microbiol Immunol. 2018 Nov;207(5-6):255-269. doi: 10.1007/s00430-018-0548-z. Epub 2018 Jul 4

23.Gao Z(#), Hu J(#), Wang X, Yang Q, Liang Y, Ma C, Liu D, Liu K, Hao X, Gu M, Liu X(*), Jiao XA, Liu X The PA‑interacting host protein nucleolin acts as an antiviral factor during highly pathogenic H5N1 avian infuenza virus infection. Arch Virol. 2018 Oct;163(10):2775-2786. doi: 10.1007/s00705-018-3926-3.

24.Hu, J ^(#), Z. Gao ^(#), X. Wang, M. Gu, X. Liu, S. Hu, H. Liu, W. Liu, S. Chen, D.Peng, X. Liu (*) iTRAQ-Based Quantitative Proteomics Reveals Important host factors Involved in the High Pathogenicity of the H5N1 avian infuenza virus in mice. Medical Microbiology and Immunology. 2017 Apr;206(2):125-147. doi: 10.1007/s00430-016-0489-3. Epub 2016 Dec 20.

25.Zhao Gao ^(#), Jiao Hu ^(#), Yanyan Liang, Qian Yang, Kun Yan, Dong Liu, Xiaoquan Wang , Min Gu, Xiaowen Liu , Shunlin Hu, Zenglei Hu, Huimou Liu, Wenbo Liu, Sujuan Chen, Daxin Peng, Xin-an Jiao and Xiufan Liu(*).Generation and Comprehensive Analysis of Host Cell Interactome of the PA Protein of the Highly Pathogenic H5N1 Avian Influenza Virus in Mammalian Cells. Frontiers in Microbiology. 2017 Apr 28;8:739. doi: 10.3389/fmicb.2017.00739

26.Hu, J (#).,Y. Mo, Z. Gao, X. Wang, M. Gu, Y. Liang, L. X. Chen, S. Hu, W. Liu, H. Liu, S. Chen, X. Liu, D. Peng and X. Liu (*).PA‑X‑associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice. Medical Microbiology and Immunology. 2016 Aug;205(4):381-95. doi: 10.1007/s00430-016-0461-2. Epub 2016 Jun 11.

27.Hu, J ^(#)., X. Liu^（*）. Endemicity of H9N2 and H5N1 Avian Influenza Viruses in Poultry in China Poses a Serious Threat to Poultry industry and Public Health. Frontiers of Agricultural Science and Engineering. 2016, 3(1): 11–24.

28. Hu, J ^(#).,Y.Mo, X. Wang, M. Gu, Z. Hu, L. Zhong, Q. Wu, X. Hao, S. Hu, W. Liu, H. Liu, X. Liu and X. Liu^（*）. PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus replication and Host Response.Journal of virology. 2015 Apr 15;89(8):4126-42.

29.Hu, J ^(#)., X. Liu^（*）. Crucial Role of PA in the Life Cycle and Host Adaptation of Influenza A Viruses. Medical Microbiology and Immunology.2015 Apr;204(2):137-49.

30. Hu, J ^(#)., Z. Hu, Q. Song, M. Gu, X. Liu, X. Wang, S. Hu, C. Chen, H. Liu, S. Chen, D.Peng, X. Liu^（*）. The PA gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of avian influenza H5N1 virus in mice.Journal of virology. March 2013;87:2660-2672.

31.Hu, J ^(#).,Z. Hu, Y. Mo, Q. Wu, Z. Cui, Z. Duan, J. Huang, H. Chen, Y. Chen, M. Gu, X. Wang, S. Hu, H. Liu, X. Liu and X. Liu^（*）. The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Responsein the Brain Contribute to the High Pathogenicity of H5N1 Avian InfluenzaVirus in Mallard Ducks. Journal of virology. October 2013,87: 11063–11075.

32.Hu, J ^(#)., K. Zhao, X. Liu, X. Wang, Z. Chen and X. Liu ^（*）. Two Highly Pathogenic Avian Influenza H5N1 Viruses of Clade 2.3.2.1 with Similar Genetic Background but with Different Pathogenicity in Mice and Ducks. Transboundary and Emerging Diseases. Apr 2013; 60(2):127-39.

33.Hu, Z ^(#)., J. Hu, S. Hu, X. Liu, X. Wang,J. Zhu and X. Liu ^（*）. 2012. Strong innate immune response and cell death in chicken splenocytes infected with genotype VIId Newcastle disease virus. Virol Journal.9:208.

34.Cui Z ^(#), J.Hu, L. He, Q. Li, M. Gu, X. Wang, S. Hu, H. Liu, W. Liu, X. Liu and X. Liu^（*）. Differential immune response of mallard duck peripheral blood mononuclear cells to two highly pathogenic avian influenza H5N1 viruses with distinct pathogenicity in mallard ducks. Archives of Virology.2014Feb;159(2):339-43.

35. Hao X (#), Hu J, Wang J, Xu J, Cheng H, Xu Y, Li Q, He D, Liu X, Wang X, Gu M, Hu S, Xu X, Liu H, Chen S, Peng D, Liu X（*）.Reassortant H5N1 avian influenza viruses containing PA or NP gene from an H9N2 virus significantly increase the pathogenicity in mice. Veterinary Microbiology. 2016 Aug 30;192:95-101.

36. Hu, J ^(#)., Zenglei Hu, Xiaowen Liu, Xiaoquan Wang, Min Gu, Shunlin Hu, Junqing Huang, Hongzhi Chen, Yuxin Chen, Yiqun Mo, Qiwen Wu, Wenbo Liu, Sujuan Chen, Daxin Peng, Xiufan Liu^（*）. The PA and HA gene contribute to the high virulence of H5N1 avian influenza virus in mallard ducks. XVIII^th World Veterinary Poutry Association.19th-23rd August 2013.Nantes.France.Oral Presentation.

37. Hu, J ^(#).,Y.Mo, X. Wang, M. Gu, Z. Hu, L. Zhong, Q. Wu, X. Hao, S. Hu, W. Liu, H. Liu, X. Liu and X. Liu^（*）. PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus replication and Host Response. 19^th World Veterinary Poutry Association.7 – 11 September 2015.Capetown.South Africa. Oral Presentation.

38. 胡娇(#)，胡增磊，莫一群，刘秀梵 (*). 禽流感病毒致死哺乳动物的分子基础研究进展.中国家禽,2013,第35卷第24期。

39. 胡娇(#)，高照，刘秀梵(*). A型流感病毒与宿主相互作用研究进展.中国家禽,2016,第38卷第24期。

四、代表专利

1. 胡娇，刘秀梵，李军，李如梦，胡增垒，王晓泉，顾敏.一种禽流感病毒样颗粒抗原、疫苗及其制备方法和应用. ZL 202011000033.8.2022年6月14号

2. 胡娇，刘秀梵，李如梦，李军，胡增垒，王晓泉，顾敏.一种重组的H7N9亚型禽流感病毒样颗粒及其制备方法和应用. ZL 202011000015.X.2022年6月14号

3. 刘秀梵，胡娇，梁艳艳，胡增垒，李如梦，王晓泉，顾敏.表达H7N9亚型禽流感病毒血凝素蛋白的重组杆状病毒灭活疫苗及其制备方法与应用. ZL 201810489385.00.2021年11月9号

4. 胡增垒，刘秀梵，张艳焱，胡娇，何晓政，邓婧.一种区分H7N9亚型禽流感病毒感染与免疫动物的多肽及其检测方法. ZL 2021 1 1263546.2.2022年6月24号

5. 胡娇,彭培培,胡增垒,刘秀梵,黄雅兰,王晓泉,顾敏,胡顺林,刘晓文.一种红细胞膜包覆的禽流感病毒样颗粒纳米疫苗及其制备方法和应用.2023102133488.2023年3月8号

6. 胡娇,刘秀梵,胡增垒,张琦,彭培培,王宇飞,胡顺林,王晓泉,顾敏,刘晓文.HA蛋白糖基化修饰模式改变的禽流感病毒样颗HA蛋白糖基化修饰模式改变的禽流感病毒样颗粒及其制备方法和应用. 202310147988.3, 2023年2月22号

7. 胡娇, 胡增垒,刘秀梵,张蕾,蔡欣欣,郑新新,刘晓文,王晓泉,胡顺林,顾敏. 一种广谱抗流感病毒的长链非编码 RNA 及其应用. 202310147990.0, 2023年2月22号

8.胡娇,胡增垒,刘秀梵,王宇飞,王晓泉,李建梅,徐思怡,顾敏,胡顺林,刘晓文.表达新型鸭呼肠孤病毒σB、σC蛋白的重组杆状病毒疫苗及其制备方法及应用.2024109478192, 2024年7月16号

9. 胡娇,胡增垒,刘秀梵,王宇飞,胡顺林,李建梅,徐思怡,顾敏,王晓泉,刘晓文.一种能够识别新型鸭呼肠孤病毒σC 蛋白的单克隆抗体、制备方法及其应用. 2024109479994, 2024年7月16号

10.胡娇,刘秀梵,胡增垒,刘晓文,王宇飞,李建梅,徐思怡,顾敏,王晓泉,胡顺林.一种能够识别新型鸭呼肠孤病毒σB 蛋白的单克隆抗体、制备方法及其应用. 2024109480008, 2024年7月16号

 

五、获批软著

1.     胡娇，刘秀梵，胡顺林，彭培培，李军. 表达H7N9亚型禽流感病毒血凝素蛋白的重组杆状病毒灭活疫苗制备管理系统V1.0. 2021SR0623457. 2021年4月29

2.     胡娇，刘秀梵，胡顺林，张琦，李如梦. 重组的H7N9亚型禽流感病毒样颗粒效力评价分析系统V1.0. 2021SR0623458. 2021年4月29

六、科研获奖

1. 2012年，扬州大学博士研究生学术新人奖

2. 2014年，江苏省优秀博士论文

3. 2016年，扬州大学“科技先锋”

4. 2021年，江苏省科学技术奖二等奖（第3完成人）

七、入选人才项目

1. 2018年，江苏高校“青蓝工程”优秀青年骨干教师

2. 2017年，扬州大学“高端人才支持计划”拔尖人才培养对象