基本资料

王磊，博士生导师，扬州大学中青年学术带头人。2019年博士毕业于华东师范大学， 导师 张俊良教授。2020年5月加入扬州大学化学化工学院，2022年11月-2023年10月在香港科技大学从事博士后研究，合作导师孙建伟教授。目前主要围绕杂环化合物的高效构建，不对称催化有机合成，金属有机化学。主持国家自然基金项目两项，江苏省青年基金一项，绿杨金凤项目一项以及扬州大学青蓝工程“扬州大学中青年学术带头人”等项目。目前以第一作者和第一通讯作者在刊发表 Sci. Adv（1篇）， JACS (3篇）, Angew (2篇）, Science China, Chem(1篇） 等国际高质量期刊文章近40篇。

科研项目 

1.  2025.01-2028.12 国家自然基金面上项目 (22471236)（主持）

2.  2022.01－2024.12  国家自然基金青年基金 (22101249)（主持）

3.  2020.07－2023.06  江苏省自然科学基金青年项目 (BK20200918)（主持）

4.  2020.5－2023.5  扬州大学高层次人才启动基金（主持）

5.  2021.03－2024.03  扬州市绿扬金凤博士（主持）

6.  2025.07-2028.06  青蓝工程 “扬州大学中青年学术带头人”（主持）

28. Xuefeng Deng, Zairan Xiao, Junmeng Ma, Lei Zeng, Qiang Dai,* and Lei Wang* Enantioselective Pd-Catalyzed Tandem Aza-Heck/Carbene Insertion for the Construction of Quaternary Stereocenter Isoindolinones. Org. Lett. 2026 , 28, doi.org/10.1021/acs.orglett.6c01921

  

27. Cangzhu Hu ‡, Xuefeng Deng ‡, Shuaijie Wua, Shuwei, Zhang,a Chenghao Zhu *, Qiang Dai, *, Junliang Zhang  and Lei Wang *Modular Enantioselective Synthesis of Tetrahydropyridazines by Palladium Catalyzed  Aminoalkenylation /Aminoarylation Reaction Chin. J. Chem. 2026,  44, 2772—2778 (‡These authors contributed equally to this work)

26. Chenyue Ding （本科生）^‡, Yuan Yin^‡, Enyu Hu, Huiwen Dong, Yanru He, Shuaijie Wu*, Ying Han* and Lei Wang*Synthesis of bisindoles scaffolds by palladium-catalyzed allylic alkylation of  N-aminoindole with ortho-iodoaryl allenes. Organic & Biomolecular Chemistry 2026, 24, 4227-4231. (‡These authors contributed equally to this work)

25. Huirong Li, Wenyu Zhang, Shuwei Zhang, Wei Jiang, Weiming Hu*, Junliang Zhang* and Lei Wang* Synthesis of fluorene-indole/benzofuran bicyclic molecules through palladium-catalyzed carboheterofunctionalization of alkynes. Chem. Commun. 2026 , 62, 9951-9954

24. Shuaijie Wu‡, Xiaomeng Xu ‡, Tian Tang, Xuefeng Deng, Shuwei Zhang, Chao-Guo Yan, Junliang Zhang *, Minyan Wang * and Lei Wang * Enantioselective Synthesis of Quaternary Stereocenter Aldehydes by PalladiumCatalyzed Intermolecular Propargylation Reaction. J. Am. Chem. Soc. 2026, doi.org/10.1021/jacs.6c00417. (‡ These authors contributed equally to this work)

23. Lei Wang,* Huiwen Dong, Cangzhu Hu, Liuzhou Gao, Qiang Dai,* and Junliang Zhang* Synthesis of Functionalized Isoxazoline N‑Oxides by Palladium- 2 Catalyzed Cyclization of Nitro-Tethered Alkenes. Org. Lett. 2026 , 28, 1, 61–66.

22. Lei Wang*, Shuaijie Wu, Wenyu Zhang, Shuting Zhang,Jieya Dong, Weiming Hu, Chengcheng Zhou*, Liuzhou Gao*, Liejin Zhou and Junliang Zhang*Enantioselective Rapid Assembly of Bis-heterocycles by Sequential Palladium-Catalyzed Aza-Heck Cyclization Coupling Reaction. Sci. Adv. 12, eaec1048 (2026)

21. Qianqian Hu ^‡, Cangzhu Hu ^‡, Tian Tang, Qing Wu, Weiming Hu*, Qiang Dai* and Lei Wang* Palladium-catalyzed aminoalkynylation/alleneamination of urea-tethered alkenes：access to imidazolidinones bearing alkyne and allene. Chem. Commun., 2025, 61, 17898-17901. (‡ These authors contributed equally to this work)

20. Qing Wu, Yingna Han (本科生), Tian Tang, Shuwei Zhang,  Xiuzhao Yu, Guofeng Zhao,* Weiming Hu,* Lei Wang*  Palladium-catalyzed tandem cyclization reaction: access to isoxazoline benzofuran bis-heterocycles. Chem. Commun., 2025, 61, 12928–12931.

19. Lei Wang,* Yanru He, Huirong Li, Shuaijie Wu, Xuefeng Deng, Wei Jiang, Liejin Zhou, Guodong Zhang Enantioselective Palladium-Catalyzed Domino Carboetherification 2 Reaction: Access to Isoxazoline-Linked Bis-Heterocycles Org. Lett. 2025,  27, 7518–7523.

18. Cangzhu Hu, Feifei Jin, Qianqian Hu, Jing Sun, Ying Han, Chaoshen Zhang*, Liejin, Zhou, Junliang Zhang* Lei Wang*Enantioselective Synthesis of Dihydropyrazoles Bearing Quaternary Stereocenter by Palladium/XuPhos-Catalyzed Tandem Reaction：Scope and Mechanistic Insights. Science China Chemistry. 2025, 68, 5804-5812. 

17. Shuaijie Wu, Shiji Xu, Yanru He, Jing Sun, Wei Jiang, Chao-Guo Yan *, Weiming Hu*, and Lei Wang* Palladium-Catalysed Alleneamination of γ,δ-unsaturated Hydrazones with Propargylic Acetates：Access to Tetrahydropyridazines Bearing Allenes. Chem. Comm. 2025, 61, 6647-6650.

16. Feifei Jin, Cangzhu Hu, Shuaijie Wu, Guodong Zhang, Ying Han, Chao-Guo Yan, Wenbo Li,* Chaoshen Zhang,*and Lei Wang*Enantioselective synthesis of isoxazolines bearing allenes by palladium-catalyzed carboetherification of β,γ-unsaturated ketoximes with propargylic acetates.Org. Chem. Front., 2025, 12, 2305-2313.

15. Lei Wang,* Wenyu Zhang, Shuaijie Wu, Qing Wu, Ying Han, Chao-Guo Yan, and Guodong Zhang*Enantioselective Synthesis of Isoindolinone by Sequential 2 Palladium-Catalyzed Aza-Heck/Suzuki Coupling Reaction. Org. Lett. 2025, 27, 235-240.

14.  Feifei Jin, Qing Wu, Shuaijie Wu, Huiwen Dong, Yanru He, Jing Sun, Chao-Guo Yan, Wenbo Li,  and Lei Wang *Palladium-Catalyzed Domino Carboetherification Reactions: Synthesis of Bis-Heterocycles Bearing Isoxazoline and  Methyleneindole Motifs. J. Org.  Chem. 2024, 89,13319-13328.

13.Yuan Yin, Cangzhu Hu, Jing Sun, Kun Huang, Chao-Guo Yan, Lei Wang,* and Ying Han* Synthesis of Indole- and       Benzofuran-Based Benzylic Sulfones by Palladium-Catalyzed Sulfonylation of ortho-Iodoaryl Allenes.  J. Org.  Chem. 2024. 89, 16653−16662

12. Feifei Jin,^‡ Qianqian Hu,^‡ Qiang Wang, Jing Sun, Kun Huang , Chao-Guo Yan, Ying Han,^* Haiyang Fei,^* Lei Wang^* Synthesis of Sulfoxides by Palladium-Catalyzed Arylation of Sulfenate anions with Aryl Thianthrenium Salts. J. Org. Chem. 2024, 89, 18, 13319–13328 (‡ These authors contributed equally to this work)

11. Cangzhu Hu^‡ Shiji, Xu^‡ Qiang Wang, Jing Sun, Ying Han, Chao-Guo Yan, Lei Wang* Synthesis of Isoxazolines and Dihydrooxazines by Pd-Catalyzed Oxyalkynylation Alkenyl Oximes with Alkynyl Bromides.  Org. Chem. Front., 2024, 11, 2768-2773 (‡ These authors contributed equally to this work)

10. Lei Wang*, Yinqiang Wang, Shuaijie Wu, Chao-Guo Yan, Chaoshen Zhang*, Junliang Zhang* and Ying Han* Enantioselective Synthesis of Isoindolinone by Palladium-Catalyzed Aminoalkynylation of O‑Phenyl Hydroxamic Ethers with Alkynes. J. Am. Chem. Soc. 2024, 146, 7, 4320–4326

9. Lei Wang*, Ruixin Chen, Shuaijie Wu, Jing Sun, Ying Han, Wenbo Li* and Chao-Guo Yan* Synthesis of Bis-Heterocycles Bearing Methyleneindole Motifs by Pd-Catalyzed Domino Reaction. J. Org. Chem. 2024, 89, 1941–1955.

8. Shiji Xu, Qiang Wang, Jing Sun, Ying Han, Weiming Hu, * Lei Wang * and Chao-Guo Yan * Pd/Cu-catalyzed cascade Heck-type reactions of alkenyl halides with terminal alkynes toward substituted pyrrolidine analogues Org. Biomol. Chem., 2023, 21, 5742–5746.

7. Shuaijie Wu, Shuting Zhang, Jing Sun, Ying Han, Yidong Wang,* Chao-Guo Yan,* and Lei Wang* Synthesis of Multisubstituted Allenes by Palladium-Catalyzed Carboetheriffcation of β,γ-Unsaturated Ketoximes with Propargylic Acetates Org. Lett. 2023, 25, 4682−4687.

6. Min Gao（本科生）, Yinqiang Wang, Shuaijie Wu, Feier Ni（本科生）, Cangzhu Hu, Feifei Jin, Jing Sun, Ying Han and Lei Wang* Synthesis of Dihydropyrazoles by Pd-Catalyzed Carboamination of Alkenyl Hydrazones with Aryl Triflates. Asian J. Org. Chem 2023, e202300182.

5.Qiang Wang, Shuaijie Wu, Yi-Dong Wang*, Jing Sun, Ying Han*, Chao-Guo Yan and Lei Wang* Transition Metal-free and Regioselective Alkenyl C−S Cross-Coupling Reaction of Alkenyl Sulfonium Salts. Org. Chem. Front., 2023, 10, 2907-2912.

4. Han Liu, Lei Wang*, Jin-Tao Yu* Radical Cascade Cyclization of Alkene-Tethered Compounds: Versatile Approach towards Ring-Fused Polycyclic Structures. Asian J. Org. Chem. doi.org/10.1002/ajoc.202300101.

3. Shuting Zhang,  Shuaijie Wu,  Qiang Wang, Shiji Xu, Ying Han, Chao-Guo Yan, Junliang Zhang*, Lei Wang*Enantioselective Synthesis Dihydropyrazoles by Palladium/Xu-Phos-Catalyzed Alleneamination of β,γ-Unsaturated Hydrazones with Propargylic Acetates. Angew. Chem. Int. Ed., 2023, 62, e202300309.

2. Lei Wang*,Shuaijie Wu, Shuting Zhang, Qianqian Hu（本科生）, Qiang Wang, Jing Sun, Ying Han*, Chao-Guo Yan*Synthesis of heterobenzyl sulfoxides enabled by Palladium-Catalyzed Allylic Alkylation of Sulfenate Anions with Allenamides J. Org. Chem. 2022, 87, 14646–14656.

1. Yinqiang Wang, Shuaijie, Wu,  Lei Wang*, Jing Sun, Chao-Guo Yan Ying Han* Synthesis of Dihydropyrazoles Enabled by Pd-Catalyzed Carboamination of Alkenyl Hydrazones with Alkenyl and Aryl Halides. Org. Chem. Front., 2022, 9, 4104–4109.

独立工作之前

1.  Lei Wang, Kenan Zhang, Yuzhuo Wang, Wenbo Li, Mingjie Chen, Junliang Zhang* Enantioselective Synthesis of Isoxazolines Enabled by Palladium Catalyzed Carboetherification of Alkenyl Oximes. Angew. Chem. Int. Ed., 2020, 59, 4421-4427.

 

2. Lei Wang, Mingjie Chen, Peichao Zhang, Wenbo Li, and Junliang Zhang* Palladium/ PC-Phos -Catalyzed Enantioselective Arylation of General Sulfenate Anions: Scope and Synthetic Applications. J. Am. Chem. Soc. 2018, 140, 3467-3473.

3. Xiao-Qing Han^‡, Lei Wang^‡, Ping Yang^‡, Jing-Yuan Liu, Wei-Yan Xu, Chao Zheng, Ren-Xiao Liang, Shu-Li You*, Junliang Zhang*, and Yi-Xia Jia*. Enantioselective Dearomative Mizoroki–Heck Reaction of Naphthalenes. ACS Catal. 2022, 12, 655-661.(^‡ These authors contributed equally to this work)

4. Lei Wang, Mingjie Chen, and Junliang Zhang* Transition metal-free base-promoted arylation of sulfenate anions with diaryliodonium salts. Org. Chem. Front. 2019, 6, 32–35.

5. Lei Wang, Wanxing Sha, Qiang Dai, Xiaomei Feng, Wenting Wu, Haibo Peng, Bin Chen, and Jiang Cheng*. The Benzoyl Peroxide Promoted Dual C−C Bond Formation via Dual C−H Bond Cleavage: α-Phenanthridinylation of Ether by Isocyanide. Org. Lett. 2014, 16, 2088-2091.

6. Lei Wang, Hui Zhu, Songjin Guo, Jiang Cheng and Jin-Tao Yu*. TBHP-promoted sequential radical silylation and aromatisation of aryl isonitriles with silanes. Chem. Commun. 2014, 50, 10864-10867.

7. Lei Wang, Xinyi Ren, Jintao Yu, Yan Jiang, and Jiang Cheng* Base-Promoted Formal Arylation of Benzo[d]oxazoles with Acyl Chloride. J. Org. Chem. 2013, 78, 12076-12081.

获奖情况                                                               

2025年江苏省科技副总（合作单位：扬州市普林斯医药科技有限公司）

2025年扬州大学最受欢迎班主任

2024 年上海市自然科学一等奖（排名第五）

2024 年Thieme Chemistry Journals Award。

      2018 年博士研究生国家奖学金

2018年博士研究生学业奖学金一等

2014年硕士研究生国家奖学金

2015年常州大学优秀硕士论文

招生方向

欢迎报考化学（有机化学），生物与医药研究方向的研究生。