扬州大学教师个人主页服务平台张小荣--中文主页-- Antibiotic resistance of Mycoplasma Synoviae strains isolated in China from 2016 to 2019

论文成果

Antibiotic resistance of Mycoplasma Synoviae strains isolated in China from 2016 to 2019

发布时间：2022-01-28点击次数：

DOI码：10.1186/s12917-021-03104-4
所属单位：扬州大学
发表刊物：BMC Veterinary Research
项目来源：财政部和农业农村部：国家现代农业产业技术体系(CARS-40)等
关键字：Mycoplasma synoviae, Antimicrobial susceptibility, Minimum inhibitory concentrations, Resistance genes, Enrofoxacin resistance
摘要：BACKGROUND: In the past decade, Mycoplasma synoviae (M. synoviae) infection has become widely prevalent in China, has caused serious economic losses and has become one of the most important diseases in the chicken industry. Medication is a general approach for the control of M. synoviae infection, but antibiotics are sometimes ineffective in clinical practice. To investigate the sensitivity of M. synoviae to antimicrobials commonly used in the treatment of M. synoviae infection, the antibiotic susceptibility of 32 M. synoviae strains isolated from China from 2016 to 2019 were determined using the minimum inhibitory concentration (MIC) method. RESULTS: All isolates had low MIC values for the combination of lincomycin and spectinomycin, pleuromutilin, and macrolides. However, the M. synoviae isolates displayed variance in MICs for doxycycline hydrochloride with a range of 0.25 to 8 mug/mL, and oxytetracycline hydrochloride with a range of 0.5 to 8 mug/mL. Three and one M. synoviae isolates showed intermediate MIC values to doxycycline hydrochloride and oxytetracycline hydrochloride, respectively. High MIC values for enrofloxacin were detected in all isolates with MICs ranging from 4 to 32 mug/mL. Furthermore, comparison of the parC QRDR identified a mutation at nucleotide position 254 (C254T) resulting in a Thr 85 Ile amino acid change in all M. synoviae isolates and the reference strain ATCC 25204 being resistant to enrofloxacin. Moreover, mutations at Glu 804 Gly and Thr 686 Ala of gyrA QRDR were identified in all M. synoviae isolates and ATCC 25204. The mutation in the QRDR of the parE gene resulted in amino acid changes at positions 197 (Pro to Ser) in 27/32 M. synoviae isolates. CONCLUSION: Three nonsynonymous mutations in gyrA and parE were first identified to be related to enrofloxacin resistance. Our results showed that M. synoviae resistance to enrofloxacin is widespread.
合写作者：郭梦娇,谢迪,陈杨,张成成,曹永忠
第一作者：张小荣
论文类型：Research Atricle
通讯作者：吴艳涛
文献类型：J
卷号：18
期号：1
页面范围：1
ISSN号：1746-6148
是否译文：否
发表时间：2022-01-03
收录刊物：SCI

附件：

Zhang-2022-Antibiotic resistance of Mycoplasma.pdf

上一条：Isolation, Serovar Identification, and Antimicrobial Susceptibility of Avibacteriumparagallinarum from Chickens in China from 2019 to 2020

下一条：血清1型禽腺病毒JS2017株感染性克隆构建及病毒拯救

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张小荣

个人信息

正高级
博士生导师
硕士生导师
教师拼音名称：Zhang Xiaorong
出生日期：1978-09-30
电子邮箱：
入职时间：2003-07-01
所在单位：兽医学院
学历：博士研究生毕业
办公地点：文汇路校区农牧南楼S203
性别：男
联系方式：E.mail:zxr@yzu.edu.cn
学位：博士
职称：正高级
在职信息：在岗
毕业院校：扬州大学
学科：预防兽医学

曾获荣誉：

2021-12-31扬州大学“十三五”科技工作先进个人
2021-10-222020-2021学年“最受学生欢迎的班主任”
2017-06-302016年江苏省普通高等学校本专科毕业设计（论文）三等奖指导教师
2016-01-182014-2015学年“最受学生欢迎的班主任”

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